Rheumatoid arthritis (RA) is an inflammatory arthritis in which joints of the hands and feet, are inflamed, which results in joint pains, swelling and frequent destruction of joints. Small joints of the limbs become painful and have stiffness which persists for about 60 minutes on awakening and after inactivity. Due to weakness, fever and damage to other organs may also occur. RA affects both sides of the body. For example, if a joint is affected in one arm or leg then a similar joint of the other arm or leg will be affected too. This is one of the ways RA is identified by the doctors from other forms of arthritis like Osteoarthritis (OA).
Rheumatoid arthritis develops in about 1% in the whole world’s population. Women are affected 2 times more than men. It appears in the age group between 35 to 50years. A similar disease in children may occur which is known as Juvenile idiopathic arthritis.
The cause of Rheumatoid arthritis is not known, it is considered as an autoimmune disease. The components of the immune system attack the soft tissues and will also attack the connective tissue in other parts of the body such as blood vessels and lungs. Due to this, gradually the bone, cartilage and the ligaments of the joints wear away causing deformity. Many unknown factors like viral infections and smoking play a vital role.
Treatments work best when RA is identified at an early stage, so it’s significant to learn the signs. Read on to acquire all you want to know about RA, from kinds and indications, to home remedies, diets, and other treatments.
People who have RA may experience these symptoms:
Joint pain, fatigue, Joint tenderness, Joint swelling, redness in joints, Joint stiffness, Loss of joint function, limping, joint deformity, both sides of the joints affected, Anemia, Fever, Depression.
Some may feel tired and weak by afternoon. RA may also cause loss of appetite with weight loss.
The signs and symptoms of RA may vary from person to person. Intense RA symptoms are known as flare-ups, and inactive periods. Other times when symptoms are less is known as remission.
The 3 tests which doctors follow to diagnose RA:
Examination of fluid joints
It is difficult to diagnose RA at early stages. There is no single test or physical finding to confirm the diagnoses. Your doctor will do a physical check-up of your joints for swelling, redness and warmth. Doctor will also test your reflexes and strength in muscles.
Blood test: The blood tests are done to find the blood levels of rheumatoid factor and Anti –CCP antibodies or C-reactive protein (CRP), ESR or both.
Rheumatoid factor test:
RF is a group of antibodies that attack the affected persons own tissues instead of attacking the harmful bacteria or viruses. If Rheumatoid factor in the blood is high then it means the autoimmune system is acting up. The RF test is mostly associated with RA but isn’t limited to that disease.
Anti – Cyclic Citrullinated protein antibody test (anti-CCP):
This test is done to find out anti-CCP antibodies in the blood. Citrulline is produced naturally in the body as part of the metabolism of the amino acid arginine. Citrulline changes the protein structure and may trigger the immune response, by producing the auto antibodies against joint proteins.
Antinuclear antibody test:
This test is done to find out the amount and pattern of antibodies in the blood that works against your own body (autoimmune reaction).
Erythrocyte sedimentation rate (ESR):
The ESR is high in people who have active rheumatoid arthritis. This test is done to know the level of inflammation and measures the speed of red blood cells settling to the bottom of a test tube containing blood sample. Normally red blood cells settle relatively slow, if they settle faster than normal rate then it indicates the inflammation in the body.
C-reactive protein test:
CRP is a blood test to check the amount of protein called C-reactive protein in the blood. This helps in measuring the general levels of inflammation in the body. Many infections and long term diseases will cause high level of CRP. This CRP test cannot identify the root cause or the location of the inflammation. Other tests are required to understand the actual cause.